Short Description

NGS genetic DNA test detecets for variant and mutation detection in COL15A1 gene for Early onset glaucoma, phenotype modifier of, COL15A1 related

PreTest Information

Clinical History of Patient who is going for COL15A1 Gene Early onset glaucoma, phenotype modifier of, COL15A1 related NGS Genetic DNA Test. A Genetic Counselling session to draw a pedigree chart of family members affected with COL15A1 Gene Early onset glaucoma, phenotype modifier of, COL15A1 related NGS Genetic DNA Test gene COL15A1

Detail Description

DNA Labs India: Understanding Early Onset Glaucoma and the COL15A1 Gene

Glaucoma is a group of eye diseases that cause damage to the optic nerve, which can lead to vision loss and blindness. Early onset glaucoma, as the name suggests, occurs at a younger age and is often more severe than the more common form of glaucoma that develops later in life.

Recent studies have shown that mutations in the COL15A1 gene can contribute to the development of early onset glaucoma. The COL15A1 gene is responsible for producing a protein that is a component of the extracellular matrix, which is essential for maintaining the health of tissues in the body.

Phenotype Modifier of COL15A1 Gene

The COL15A1 gene is not a direct cause of early onset glaucoma but is considered a phenotype modifier. This means that mutations in the COL15A1 gene can modify the expression of other genes that are directly linked to the development of early onset glaucoma.

Researchers have found that mutations in the COL15A1 gene can lead to changes in the extracellular matrix of the trabecular meshwork, which is responsible for regulating the flow of fluid in the eye. This can cause an increase in intraocular pressure, which is a major risk factor for the development of glaucoma.

COL15A1 Related NGS Genetic DNA Test

The COL15A1 related NGS Genetic DNA Test is a genetic test that can help identify mutations in the COL15A1 gene. This test uses next-generation sequencing (NGS) technology, which allows for the analysis of multiple genes at once.

The cost of the COL15A1 related NGS Genetic DNA Test is INR 20,000. This test is performed on a blood or saliva sample and can provide valuable information about an individual's risk of developing early onset glaucoma.

Symptoms and Diagnosis of Early Onset Glaucoma

Early onset glaucoma often has no symptoms in its early stages, which is why it is often referred to as the "silent thief of sight." As the disease progresses, symptoms may include:

• Blurred vision
• Loss of peripheral vision
• Halos around lights
• Eye pain
• Headaches

Diagnosis of early onset glaucoma typically involves a comprehensive eye exam, including a measurement of intraocular pressure, a visual field test, and an examination of the optic nerve. If early onset glaucoma is suspected, genetic testing may be recommended to identify mutations in genes such as COL15A1 that can contribute to the disease.

Conclusion

Early onset glaucoma is a serious eye disease that can cause vision loss and blindness. Mutations in the COL15A1 gene are a phenotype modifier that can contribute to the development of early onset glaucoma. The COL15A1 related NGS Genetic DNA Test is a valuable tool that can help identify these mutations and provide valuable information about an individual's risk of developing the disease.

If you are concerned about your risk of developing early onset glaucoma, speak to your healthcare provider about the COL15A1 related NGS Genetic DNA Test and other genetic tests that may be recommended. Early detection and treatment of glaucoma can help prevent vision loss and improve outcomes for individuals with the disease.

At DNA Labs India, we offer a wide range of genetic testing services, including the COL15A1 related NGS Genetic DNA Test. Contact us today to learn more about our services and how we can help you better understand your genetic makeup.