Short Description

A reactive, benign B-cell proliferation is characterized by polyclonal expansion of B-cells whereas a malignant process is often characterized by a clonal expansion of a predominant B-cell population. In conjunction with histopathology study of lymph nodes, bone marrow and other tissue types, the detection of a clonal immunoglobulin heavy chain gene rearrangement by polymerase chain reaction (PCR) is intended as an aid in the diagnosis of malignant B-cell lymphoma.

PreTest Information

Duly filled Genomics Clinical Information Requisition Form (Form 20) is mandatory.

Detail Description

B-CELL REARRANGEMENT DETECTION Test: Cost, Symptoms and Diagnosis

B-cell rearrangement detection test is a specialized test that helps to identify the clonality of B-cells in the body. This test is commonly used in the diagnosis of lymphomas and leukemias. The test is based on the principle that each B-cell has a unique DNA sequence that is rearranged during the development of the immune system. Any abnormality in this rearrangement process can lead to the development of cancerous B-cells.

Cost of B-cell rearrangement detection test

The cost of B-cell rearrangement detection test in India varies depending on the location and testing facility. On average, the test can cost around INR 22,000. However, the cost may increase depending on additional tests or procedures that may be required for diagnosis. It is recommended to consult with a healthcare provider to determine the exact cost of the test.

Symptoms of B-cell lymphomas and leukemias

B-cell lymphomas and leukemias can cause a range of symptoms, including:

• Swollen lymph nodes
• Fever
• Night sweats
• Unexplained weight loss
• Fatigue
• Loss of appetite
• Bone pain
• Shortness of breath
• Persistent cough

If these symptoms persist for an extended period, it is recommended to consult with a healthcare provider for proper diagnosis and treatment.

Diagnosis of B-cell lymphomas and leukemias

B-cell rearrangement detection test is an essential tool in the diagnosis of B-cell lymphomas and leukemias. The healthcare provider may order additional tests, such as imaging scans, blood tests, and bone marrow biopsy, to confirm the diagnosis. The B-cell rearrangement detection test can help to determine the clonality of B-cells and the type of lymphoma or leukemia.

In conclusion, the B-cell rearrangement detection test is an essential test that can aid in the diagnosis of B-cell lymphomas and leukemias. The test cost may vary depending on the location and testing facility, but it is recommended to consult with a healthcare provider for proper diagnosis and treatment.

Looking for B-cell rearrangement detection test?

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