Short Description

NGS genetic DNA test detecets for variant and mutation detection in ATL1 gene for SPG3A

PreTest Information

Clinical History of Patient who is going for ATL1 Gene SPG3A NGS Genetic DNA Test A Genetic Counselling session to draw a pedigree chart of family members affected with ATL1 Gene SPG3A

Detail Description

ATL1 Gene SPG3A NGS Genetic DNA Test: Symptoms, Diagnosis, and Cost in India

DNA Labs India offers the ATL1 Gene SPG3A NGS Genetic DNA test for individuals experiencing symptoms related to hereditary spastic paraplegia (HSP). HSP is a group of neurological disorders that affect the spinal cord, leading to difficulty in walking and movement. The ATL1 Gene SPG3A NGS Genetic DNA test is a diagnostic tool that helps in identifying the genetic cause of HSP symptoms. In this blog, we will discuss the symptoms, diagnosis, and cost of the ATL1 Gene SPG3A NGS Genetic DNA test in India.

Symptoms of HSP

The symptoms of HSP may vary depending on the type of disorder and its severity. However, some common symptoms of HSP include:

• Difficulty in walking and movement
• Stiffness and spasticity in the legs
• Decreased sensation in the legs and feet
• Urinary urgency and incontinence
• Difficulty with balance and coordination

It is important to note that not all individuals with HSP will experience all these symptoms. Some individuals may have mild symptoms, while others may have severe symptoms that affect their daily activities.

Diagnosis of HSP

The diagnosis of HSP involves a thorough evaluation of the patient's medical history, physical examination, and genetic testing. The physical examination may include testing the patient's reflexes, muscle tone, and gait. The genetic testing is done to identify the specific gene mutation that is causing the HSP symptoms. The ATL1 Gene SPG3A NGS Genetic DNA test is one such genetic test that helps in identifying the ATL1 gene mutation that causes SPG3A HSP.

ATL1 Gene SPG3A NGS Genetic DNA Test

The ATL1 Gene SPG3A NGS Genetic DNA test is a next-generation sequencing (NGS) test that analyzes the entire ATL1 gene for mutations. The test is done using a blood sample or a cheek swab, and the results are available within 2-3 weeks. The test can identify mutations in the ATL1 gene that cause SPG3A HSP, which is a rare form of HSP that affects the legs and lower body.

Cost of ATL1 Gene SPG3A NGS Genetic DNA Test in India

The cost of the ATL1 Gene SPG3A NGS Genetic DNA test in India is INR 20,000. This cost includes the genetic testing, interpretation of results, and genetic counseling. The genetic counseling is provided to individuals who test positive for the ATL1 gene mutation to help them understand the implications of the test results and make informed decisions about their healthcare.

Conclusion

The ATL1 Gene SPG3A NGS Genetic DNA test is a valuable diagnostic tool for individuals experiencing symptoms related to HSP. The test can identify the specific gene mutation that is causing the symptoms, which can help in developing an effective treatment plan. The cost of the test in India is INR 20,000, which includes genetic counseling. If you or a loved one is experiencing symptoms of HSP, it is important to seek medical attention and consider genetic testing to identify the underlying cause of the symptoms.

For more information on the ATL1 Gene SPG3A NGS Genetic DNA test, visit DNA Labs India's website.

SPG3A, also known as hereditary spastic paraplegia type 3A, is a rare genetic disorder characterized by progressive muscle stiffness and weakness, primarily affecting the lower limbs. Mutations in the ATL1 gene are associated with SPG3A. The ATL1 gene encodes a protein called atlastin-1, which plays a role in maintaining the structure and function of nerve cells.

The ATL1 Gene SPG3A NGS Genetic DNA Test is a diagnostic test that utilizes Next-Generation Sequencing (NGS) technology to analyze the ATL1 gene for potential mutations or variants linked to SPG3A. This genetic test helps identify individuals who have mutations in the ATL1 gene that are causing or contributing to their hereditary spastic paraplegia.

During the test, DNA is extracted from a patient's sample, typically from blood. The DNA is then sequenced to examine the coding regions and other important regions of the ATL1 gene. Any mutations, deletions, or other genetic changes that are detected can provide valuable information about the genetic basis of the individual's condition. This information can assist in confirming a diagnosis, predicting the progression of the disorder, and guiding treatment and management strategies.

Interpreting the results of genetic tests such as the ATL1 Gene SPG3A NGS Genetic DNA Test requires the expertise of medical professionals, genetic counselors, or specialists who are knowledgeable about the condition. They can provide information, counseling, and support to help individuals and families understand the implications of the genetic findings and make informed decisions about their health care.