Short Description

This assay is useful for evaluating patients suspected of having Autoimmune vasculitis, both Wegener's granulomatosis and Microscopic Polyangiitis. Autoantibodies to PR3 (c-ANCA) occur in patients with classical / limited end-organ involvement Wegener's granulomatosis. Antibodies to MPO (p-ANCA) occur predominantly in patients with Microscopic Polyangiitis.

PreTest Information

Overnight fasting is preferred.

Detail Description

ANCA (ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES) IFA IN DILUTIONS

ANCA (Antineutrophil Cytoplasmic Antibodies) IFA in Dilutions is a diagnostic test that helps detect the presence of ANCA antibodies in the blood. These antibodies are associated with autoimmune diseases such as vasculitis, a condition in which blood vessels become inflamed and damaged.

What are ANCA antibodies?

ANCA antibodies are autoantibodies that attack and damage neutrophils, a type of white blood cell that helps fight infections. These antibodies target proteins in the cytoplasm of neutrophils, resulting in their destruction and release of harmful substances that cause inflammation and tissue damage.

What is ANCA IFA in Dilutions test?

The ANCA IFA in Dilutions test is a blood test that detects the presence of ANCA antibodies in the blood. It uses indirect immunofluorescence (IFA) to detect the antibodies. In this test, the patient's blood serum is mixed with neutrophils that have been fixed onto a slide. If ANCA antibodies are present in the blood, they will bind to the fixed neutrophils. The slide is then examined under a microscope with fluorescent light, and if the antibodies are present, they will emit a bright fluorescent signal.

Why is ANCA IFA in Dilutions test performed?

The ANCA IFA in Dilutions test is performed to diagnose autoimmune diseases such as vasculitis, Wegener's granulomatosis, microscopic polyangiitis, and Churg-Strauss syndrome. These diseases are characterized by inflammation and damage to blood vessels, which can affect various organs in the body such as the kidneys, lungs, and skin.

What are the symptoms of ANCA-associated vasculitis?

The symptoms of ANCA-associated vasculitis depend on the organs affected. The common symptoms include:

• Fever
• Fatigue
• Weight loss
• Joint pain
• Shortness of breath
• Cough
• Blood in urine
• Skin rash or sores
• Eye pain or vision changes
• Numbness or tingling in hands or feet

How is ANCA-associated vasculitis diagnosed?

ANCA-associated vasculitis is diagnosed based on a combination of clinical symptoms, laboratory tests, and imaging studies. The ANCA IFA in Dilutions test is one of the laboratory tests used to confirm the diagnosis. Other tests include:

• Complete blood count (CBC)
• Kidney function tests
• Urinalysis
• Chest X-ray or CT scan
• Biopsy of affected tissue

What is the cost of ANCA IFA in Dilutions test in India?

The cost of ANCA IFA in Dilutions test in India is around INR 5000. The cost may vary depending on the location and the laboratory performing the test.

Conclusion

The ANCA IFA in Dilutions test is a useful diagnostic tool for the detection of ANCA antibodies in the blood. This test is important in the diagnosis of ANCA-associated vasculitis, a group of autoimmune diseases that cause inflammation and damage to blood vessels. If you are experiencing any of the symptoms associated with ANCA-associated vasculitis, it is important to consult a healthcare provider for proper evaluation and diagnosis.

For more information on ANCA IFA in Dilutions test, visit DNA Labs India.