Short Description

5-Flurouracil (5-FU) Toxicity and Chemotherapeutic Response (DPYD variants) is performed using Sanger Sequencing methodology. Sample that have to be given is Peripheral blood in EDTA Vacutainer (2ml) for this test. You can expect results in 3-4 days

PreTest Information

5-Flurouracil (5-FU) Toxicity and Chemotherapeutic Response (DPYD variants) can be done with a Doctor’s prescription. Prescription is not applicable for surgery and pregnancy cases or people planing to travel abroad.

Detail Description

5-Fluorouracil (5-FU) Toxicity and Chemotherapeutic Response (DPYD Variants)

Chemotherapy is a common treatment for cancer patients. One of the drugs used is 5-fluorouracil (5-FU). However, some patients may experience toxicity when taking this drug. This is due to the presence of DPYD variants. In this blog, we will discuss the symptoms, diagnosis, and cost of 5-FU toxicity and chemotherapeutic response caused by DPYD variants.

Symptoms

The symptoms of 5-FU toxicity can vary from patient to patient. Some common symptoms include:

• Nausea and vomiting
• Diarrhea
• Fever
• Mouth sores
• Low white blood cell count

If you experience any of these symptoms, it is important to inform your doctor immediately.

Diagnosis

DPYD variants can be detected through genetic testing. Your doctor may recommend genetic testing before you start chemotherapy to determine if you have any DPYD variants that could cause toxicity.

If you have already started chemotherapy and are experiencing symptoms of 5-FU toxicity, your doctor may order a blood test to check your white blood cell count and liver function. They may also perform a physical exam to check for mouth sores and other symptoms.

Chemotherapeutic Response

DPYD variants can also affect a patient's response to chemotherapy. Patients with DPYD variants may not respond as well to 5-FU chemotherapy as patients without the variants.

However, there are other chemotherapy drugs that can be used instead of 5-FU for patients with DPYD variants. Your doctor will work with you to determine the best course of treatment based on your individual needs.

Cost

The cost of genetic testing for DPYD variants can vary depending on the lab and location. At DNA Labs India, the cost for DPYD variant testing is INR 5250.

While this may seem like a high cost, it is important to remember that genetic testing can provide valuable information about your individual risk for 5-FU toxicity and guide your treatment plan.

Conclusion

5-FU toxicity caused by DPYD variants can be a serious concern for cancer patients. It is important to be aware of the symptoms and inform your doctor if you experience any of them. Genetic testing can help determine if you are at risk for 5-FU toxicity and guide your treatment plan. While the cost of genetic testing may be high, it can provide valuable information to improve your overall care.